Supplementary Materials

Supplementary Materials for:

The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor–1 Ligands

Andrey Anisimov, Veli-Matti Leppänen, Denis Tvorogov, Georgia Zarkada, Michael Jeltsch, Tanja Holopainen, Seppo Kaijalainen, Kari Alitalo*

*Corresponding author. E-mail: kari.alitalo{at}helsinki.fi

This PDF file includes:

  • Fig. S1. Comparison of the amino acid sequences of VEGFR-1 ligand loops.
  • Fig. S2. Replacement of VEGF-A L1 with the VEGF-B–derived L1 does not affect VEGFR-1 binding, but inhibits VEGFR-1 activation.
  • Fig. S3. Pretreatment of PAE–VEGFR-2 cells with high molar excess of VEGF-B does not reduce the VEGFR-2 phosphorylation induced by B-L1P or VEGF-A.
  • Fig. S4. Analysis of L1 swap chimeras between VEGF-A and PlGF.

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Citation: A. Anisimov, V.-M. Leppänen, D. Tvorogov, G. Zarkada, M. Jeltsch, T. Holopainen, S. Kaijalainen, K. Alitalo, The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor–1 Ligands. Sci. Signal. 6, ra52 (2013).

© 2013 American Association for the Advancement of Science