Supplementary Materials

Supplementary Materials for:

Phosphatidylcholine Transfer Protein Interacts with Thioesterase Superfamily Member 2 to Attenuate Insulin Signaling

Baran A. Ersoy, Akansha Tarun, Katharine D'Aquino, Nancy J. Hancer, Chinweike Ukomadu, Morris F. White, Thomas Michel, Brendan D. Manning, David E. Cohen*

*Corresponding author. E-mail: dcohen@partners.org

This PDF file includes:

  • Fig. S1. Roles of PI3K, mTORC2, PTEN, oxidative stress, PKA, MAPK, PLC, and AMPK in the inhibition of Akt activity by PC-TP and THEM2.
  • Fig. S2. Inhibition of IRS2 by PC-TP.
  • Fig. S3. Characterization of a mouse antibody to phosphorylated IRS2 at Ser924.
  • Fig. S4. Compound A1–mediated disruption of PC-TP interactions with THEM2 and TSC2.
  • Fig. S5. Inhibition of TSC2 phosphorylation by PC-TP and THEM2.

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Citation: B. A. Ersoy, A. Tarun, K. D'Aquino, N. J. Hancer, C. Ukomadu, M. F. White, T. Michel, B. D. Manning, D. E. Cohen, Phosphatidylcholine Transfer Protein Interacts with Thioesterase Superfamily Member 2 to Attenuate Insulin Signaling. Sci. Signal. 6, ra64 (2013).

© 2013 American Association for the Advancement of Science