Supplementary Materials

Supplementary Materials for:

The Chemokine CXCL12 Generates Costimulatory Signals in T Cells to Enhance Phosphorylation and Clustering of the Adaptor Protein SLP-76

Xin Smith, Helga Schneider, Karsten Köhler, Hebin Liu, Yuning Lu, Christopher E. Rudd*

*Corresponding author. E-mail: cer51@cam.ac.uk

This PDF file includes:

  • Fig. S1. CXCL12 enhances the anti-CD3–dependent formation of SLP-76 microclusters and their stability.
  • Fig. S2. Soluble CXCL12 increases the extent of anti-CD3–dependent SLP-76 microcluster formation.
  • Fig. S3. CXCL12 slows the movement of SLP-76 microclusters and actin.
  • Fig. S4. CXCL12 preferentially enhances the anti-CD3–dependent phosphorylation of SLP-76 at Tyr113 and Tyr128.

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Citation: X. Smith, H. Schneider, K. Köhler, H. Liu, Y. Lu, C. E. Rudd, The Chemokine CXCL12 Generates Costimulatory Signals in T Cells to Enhance Phosphorylation and Clustering of the Adaptor Protein SLP-76. Sci. Signal. 6, ra65 (2013).

© 2013 American Association for the Advancement of Science