Supplementary Materials

Supplementary Materials for:

The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis

Chunling Yi,* Zhewei Shen, Anat Stemmer-Rachamimov, Noor Dawany, Scott Troutman, Louise C. Showe, Qin Liu, Akihiko Shimono, Marius Sudol, Lars Holmgren, Ben Z. Stanger,* Joseph L. Kissil*

*Corresponding author. E-mail: jkissil@scripps.edu (J.L.K.); bstanger@exchange.upenn.edu (B.Z.S.); cy232@georgetown.edu (C.Y.)

This PDF file includes:

  • Fig. S1. The Amotflox allele incompletely recombines in the tumor regions of livers in DKO mice.
  • Fig. S2. An LPxY motif on Amot-p130 mediates its binding to Yap.
  • Fig. S3. Sequence alignment of human Amot-p80, Amot-p130, AmotL1, and AmotL2 proteins.
  • Fig. S4. Amot-p130 specifically blocks Yap-Lats1 interaction.
  • Fig. S5. Yap and Amot co-regulate a large set of genes.
  • Fig. S6. Yap requires Amot for its transcriptional regulatory activity.
  • Legends for tables S1 to S3

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Technical Details

Format: Adobe Acrobat PDF

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Commonly regulated genes by Yap and Amot.
  • Table S2 (Microsoft Excel format). Pathways predicted to be regulated by Amot or Yap by GSEA.
  • Table S3 (Microsoft Excel format). Primer sequences.

[Download Table S1 to S3]


Citation: C. Yi, Z. Shen, A. Stemmer-Rachamimov, N. Dawany, S. Troutman, L. C. Showe, Q. Liu, A. Shimono, M. Sudol, L. Holmgren, B. Z. Stanger, J. L. Kissil, The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis. Sci. Signal. 6, ra77 (2013).

© 2013 American Association for the Advancement of Science