Supplementary Materials

Supplementary Materials for:

A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif

Mark Linch, Marta Sanz-Garcia, Erika Soriano, Yixiao Zhang, Philippe Riou, Carine Rosse, Angus Cameron, Phillip Knowles, Andrew Purkiss, Svend Kjaer, Neil Q. McDonald,* Peter J. Parker*

*Corresponding author. E-mail: peter.parker@cancer.org.uk (P.J.P.); neil.mcdonald@cancer.org.uk (N.Q.M.)

This PDF file includes:

  • Fig. S1. Kinetic studies of the PKCι suggest a role in protein-protein binding rather than trans-activation.
  • Fig. S2. The RIPR motif in PKCι alters the pattern of phalloidin staining in MDCK cysts.
  • Fig. S3. Western blot showing exogenous and endogenous PKCι in the MDCK cell lines used in Fig. 6.

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Citation: M. Linch, M. Sanz-Garcia, E. Soriano, Y. Zhang, P. Riou, C. Rosse, A. Cameron, P. Knowles, A. Purkiss, S. Kjaer, N. Q. McDonald, P. J. Parker, A Cancer-Associated Mutation in Atypical Protein Kinase Cι Occurs in a Substrate-Specific Recruitment Motif. Sci. Signal. 6, ra82 (2013).

© 2013 American Association for the Advancement of Science