Supplementary Materials

Supplementary Materials for:

Heteromeric MT1/MT2 Melatonin Receptors Modulate Photoreceptor Function

Kenkichi Baba, Abla Benleulmi-Chaachoua, Anne-Sophie Journé, Maud Kamal, Jean-Luc Guillaume, Sébastien Dussaud, Florence Gbahou, Katia Yettou, Cuimei Liu, Susana Contreras-Alcantara, Ralf Jockers,* Gianluca Tosini*

*Corresponding author. E-mail: gtosini@msm.edu (G.T.); ralf.jockers@inserm.fr (R.J.)

This PDF file includes:

  • Fig. S1. Flag and Myc immunoreactivity in the photoreceptors Flag-MT1 and Myc- MT2 mice.
  • Fig. S2. Competition binding of 2-[125I]iodomelatonin on membranes of HEK293 cells expressing mouse MT1 and MT2.
  • Fig. S3. The effect of luzindole and 4P-PDOT on the ERG.
  • Fig. S4. Functional characterization of the MT2-P95L mutant in transfected HEK293T cells.
  • Fig. S5. The effect of different signaling pathway stimulators and inhibitors on the amplitude of the a-wave at 7 ms.
  • Fig. S6. Inhibition of melatonin-induced IP production by 4P-PDOT.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 988 KB


Citation: K. Baba, A. Benleulmi-Chaachoua, A.-S. Journé, M. Kamal, J.-L. Guillaume, S. Dussaud, F. Gbahou, K. Yettou, C. Liu, S. Contreras-Alcantara, R. Jockers, G. Tosini, Heteromeric MT1/MT2 Melatonin Receptors Modulate Photoreceptor Function. Sci. Signal. 6, ra89 (2013).

© 2013 American Association for the Advancement of Science