Supplementary Materials

Supplementary Materials for:

The Duration of T Cell Stimulation Is a Critical Determinant of Cell Fate and Plasticity

Natasa Miskov-Zivanov, Michael S. Turner, Lawrence P. Kane, Penelope A. Morel,* James R. Faeder*

*Corresponding author. E-mail: morel@pitt.edu (P.A.M.); faeder@pitt.edu (J.R.F.)

This PDF file includes:

  • Fig. S1. Behaviors of Foxp3 and IL-2 for different delay setups in scenarios of high and low doses of antigen.
  • Fig. S2. System trajectories for different delay setups in scenarios of high and low doses of antigen.
  • Fig. S3. Frequency with which attractors A1 to A11 occur in the antigen removal scenarios T1 to T12.
  • Fig. S4. Analysis of the effects of different delay setups for the scenario of stimulation with a high dose of antigen followed by antigen removal.
  • Fig. S5. Signal propagation and element trajectories of different attractors in scenario T6.
  • Fig. S6. Transient behavior and phenotypes in the presence of inhibitors and a high dose of antigen.
  • Fig. S7. Analysis of the effects of switching model elements OFF.
  • Fig. S8. Analysis of the effects of randomizing initial values of model elements.
  • Table S1. Model elements.
  • Table S2. Model rules.
  • Table S3. Initial element values for several scenarios.
  • Table S4. Computation of numbers for heat maps.
  • References for tables S1 and S2.

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Citation: N. Miskov-Zivanov, M. S. Turner, L. P. Kane, P. A. Morel, J. R. Faeder, The Duration of T Cell Stimulation Is a Critical Determinant of Cell Fate and Plasticity. Sci. Signal. 6, ra97 (2013).

© 2013 American Association for the Advancement of Science