Supplementary Materials

Supplementary Materials for:

Protein Tyrosine Phosphatase 1B Is a Regulator of the Interleukin-10–Induced Transcriptional Program in Macrophages

Kelly A. Pike, Andrew P. Hutchins, Valerie Vinette, Jean-François Théberge, Laurent Sabbagh, Michel L. Tremblay,* Diego Miranda-Saavedra*

*Corresponding author. E-mail: michel.tremblay@mcgill.ca (M.L.T.); diego.miranda-saavedra@ncl.ac.uk (D.M.-S.)

This PDF file includes:

  • Fig. S1. IL-10 stimulates the production of PTP1B protein.
  • Fig. S2. Phenotypic and transcriptional comparison of peritoneal macrophages from PTP1B+/+, PTP1B+/−, and PTP1B−/− mice.
  • Fig. S3. IL-6 does not induce Ptpn1 expression.
  • Fig. S4. Loss of PTP1B does not induce IFN-g production.
  • Fig. S5. PTP1B is required to regulate the IL-10–induced transcriptional program.
  • Table S1. Selected genes from the RNA-seq gene set.

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Citation: K. A. Pike, A. P. Hutchins, V. Vinette, J.-F. Théberge, L. Sabbagh, M. L. Tremblay, D. Miranda-Saavedra, Protein Tyrosine Phosphatase 1B Is a Regulator of the Interleukin-10–Induced Transcriptional Program in Macrophages. Sci. Signal. 7, ra43 (2014).

© 2014 American Association for the Advancement of Science