Supplementary Materials

Supplementary Materials for:

T Cell Receptor–Dependent Activation of mTOR Signaling in T Cells Is Mediated by Carma1 and MALT1, But Not Bcl10

Kristia S. Hamilton, Binh Phong, Catherine Corey, Jing Cheng, Balachandra Gorentla, Xiaoping Zhong, Sruti Shiva, Lawrence P. Kane*

*Corresponding author. E-mail: lkane@pitt.edu

This PDF file includes:

  • Fig. S1. Analysis of total S6 and Carma1 protein abundance in parental and mutant Jurkat cell lines.
  • Fig. S2. Analysis of mTOR and TSC phosphorylation and of 4E-BP1 abundance in Carma1-deficient cells.
  • Fig. S3. Specificity of kinase inhibitors and comparison of the extent of 4E-BP1 phosphorylation in T cells lacking either Bcl10 or MALT1.
  • Fig. S4. The MALT1 inhibitor z-VRPR-fmk has a limited repertoire of effects on T cell activation.

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Citation: K. S. Hamilton, B. Phong, C. Corey, J. Cheng, B. Gorentla, X. Zhong, S. Shiva, L. P. Kane, T Cell Receptor–Dependent Activation of mTOR Signaling in T Cells Is Mediated by Carma1 and MALT1, But Not Bcl10. Sci. Signal. 7, ra55 (2014).

© 2014 American Association for the Advancement of Science