Supplementary Materials

Supplementary Materials for:

The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells

Vivian Gama, Vijay Swahari, Johanna Schafer, Adam J. Kole, Allyson Evans, Yolanda Huang, Anna Cliffe, Brian Golitz, Noah Sciaky, Xin-Hai Pei, Yue Xiong, Mohanish Deshmukh*

*Corresponding author. E-mail: mohanish@med.unc.edu

This PDF file includes:

  • Fig. S1. Degradation of mitochondrially released Cyt c in neurons, cardiomyocytes, and myotubes.
  • Fig. S2. Cyt c ubiquitination and degradation in Apaf-1–deficient cells.
  • Fig. S3. Inhibition of Cyt c degradation in PARC/CUL9-deficient cells.
  • Fig. S4. PARC/CUL9 overexpression inhibits cell death after MOMP.
  • Table S1. List of genes included in the siRNA library of human E3 ligases from Dharmacon.

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Citation: V. Gama, V. Swahari, J. Schafer, A. J. Kole, A. Evans, Y. Huang, A. Cliffe, B. Golitz, N. Sciaky, X.-H. Pei, Y. Xiong, M. Deshmukh, The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells. Sci. Signal. 7, ra67 (2014).

© 2014 American Association for the Advancement of Science