Supplementary Materials

Supplementary Materials for:

Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration

Juliane Mooz, Tripat Kaur Oberoi-Khanuja, Gregory S. Harms, Weiru Wang, Bijay S. Jaiswal, Somasekar Seshagiri, Ritva Tikkanen, Krishnaraj Rajalingam*

*Corresponding author. E-mail: krishna@biochem2.de

This PDF file includes:

  • Fig. S1. ARAF is critically required for RAF inhibitor–mediated MAPK activation.
  • Fig. S2. Role for ARAF in regulating tumor cell migration.
  • Fig. S3. Requirement of specific RAF isoforms for MAPK activation in response to various RAS mutants.
  • Fig. S4. Dimerization of ARAF promotes MAPK activation.
  • Fig. S5. Competition between RAF isoforms for binding to MEK1.

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Citation: J. Mooz, T. K. Oberoi-Khanuja, G. S. Harms, W. Wang, B. S. Jaiswal, S. Seshagiri, R. Tikkanen, K. Rajalingam, Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration. Sci. Signal. 7, ra73 (2014).

© 2014 American Association for the Advancement of Science