Supplementary Materials

Supplementary Materials for:

The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice

Simona Infantino, Sarah A. Jones, Jennifer A. Walker, Mhairi J. Maxwell, Amanda Light, Kristy O'Donnell, Evelyn Tsantikos, Victor Peperzak, Toby Phesse, Matthias Ernst, Fabienne Mackay, Margaret L. Hibbs, Kirsten A. Fairfax, David M. Tarlinton*

*Corresponding author. E-mail: tarlinton@wehi.edu.au

This PDF file includes:

  • Fig. S1. Lyn−/− mice accumulate plasma cells with an increased abundance of Blimp-1.
  • Fig. S2. B cells from Lyn−/− and wild-type mice differentiate similarly in vitro.
  • Fig. S3. Analysis of spleen size and B cell numbers in chimeric mice generated by bone marrow reconstitution.
  • Fig. S4. The cell surface abundance of CXCR4 is similar on plasma cells from wild-type and Lyn−/−Il6−/− mice.
  • Fig. S5. Plasma cells from Lyn−/− and wild-type mice exhibit similar survival kinetics in the presence of IL-21, BAFF, and Flt3L.
  • Fig. S6. Analysis of the cell surface abundance of CD123 on plasma cells.
  • Fig. S7. JAK1/2 inhibition in Lyn−/− mice with AZD1480.
  • Fig. S8. Effects of treatment of plasma cells with PP2 in vitro.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 568 KB


Citation: S. Infantino, S. A. Jones, J. A. Walker, M. J. Maxwell, A. Light, K. O'Donnell, E. Tsantikos, V. Peperzak, T. Phesse, M. Ernst, F. Mackay, M. L. Hibbs, K. A. Fairfax, D. M. Tarlinton, The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice. Sci. Signal. 7, ra77 (2014).

© 2014 American Association for the Advancement of Science