Supplementary Materials

Supplementary Materials for:

Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections

Kong-Yan Wu, Miao He, Qiong-Qiong Hou, Ai-Li Sheng, Lei Yuan, Fei Liu, Wen-Wen Liu, Guangpu Li, Xing-Yu Jiang, Zhen-Ge Luo*

*Corresponding author. E-mail: zgluo@ion.ac.cn

This PDF file includes:

  • Fig. S1. Quantification of protein interactions.
  • Fig. S2. Rab5 distribution in brain slices and cultured cortical neurons.
  • Fig. S3. Regulation of Rab5 activity by other guidance cues.
  • Fig. S4. Efficacy and specificity of the GST-R5BD probe in cultured L2/3 neurons.
  • Fig. S5. Specificity of Rab5 siRNA and role of Rab10 in axonal growth cones.
  • Fig. S6. Recognition of cortical regions after electroporation.
  • Fig. S7. Role of Rab5 isoforms in cortical neuron migration.
  • Fig. S8. Role of Rab5b in cortical neuron migration.
  • Fig. S9. Effects of Rab5 manipulations on the differentiation of cortical neural progenitors.

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Citation: K.-Y. Wu, M. He, Q.-Q. Hou, A.-L. Sheng, L. Yuan, F. Liu, W.-W. Liu,G. Li, X.-Y. Jiang, Z.-G. Luo, Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections. Sci. Signal. 7, ra81 (2014).

© 2014 American Association for the Advancement of Science