Supplementary Materials

Supplementary Materials for:

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma

Ganesh Umapathy, Abeer El Wakil, Barbara Witek, Louis Chesler, Laura Danielson, Xianming Deng, Nathanael S. Gray, Mikael Johansson, Samuel Kvarnbrink, Kristina Ruuth, Christina Schönherr, Ruth H. Palmer, Bengt Hallberg*

*Corresponding author. E-mail: bengt.hallberg{at}gu.se

This PDF file includes:

  • Fig. S1. Activation of ERK5 in PC12 cells expressing wild-type hALK or hALKF1174S.
  • Fig. S2. Abundance of MYCN in neuroblastoma cells is decreased in response to XMD8-92.
  • Fig. S3. Putative AKT phosphorylation sites in MEKK3.
  • Fig. S4. siRNA-mediated suppression of ERK5 decreases the proliferation of neuroblastoma cells.
  • Fig. S5. ERK5 and MYCN are activated as downstream targets of ALK.
  • Table S1. XMD8-92 acts synergistically with crizotinib to inhibit neuroblastoma cell line proliferation.

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Citation: G. Umapathy, A. El Wakil, B. Witek, L. Chesler, L. Danielson, X. Deng, N. S. Gray, M. Johansson, S. Kvarnbrink, K. Ruuth, C. Schönherr, R. H. Palmer, B. Hallberg, The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma. Sci. Signal. 7, ra102 (2014).

© 2014 American Association for the Advancement of Science