Supplementary Materials

Supplementary Materials for:

Annotation of human cancers with EGFR signaling–associated protein complexes using proximity ligation assays

Matthew A. Smith, Richard Hall, Kate Fisher, Scott M. Haake, Farah Khalil, Matthew B. Schabath, Vincent Vuaroqueaux, Heinz-Herbert Fiebig, Soner Altiok, Yian Ann Chen, Eric B. Haura*

*Corresponding author. E-mail: eric.haura{at}moffitt.org

This PDF file includes:

  • Fig. S1. PLA assay schematic.
  • Fig. S2. Phosphorylated Tyr1068 EGFR in xenografts.
  • Fig. S3. Distribution of PDX tumors.
  • Fig. S4. Distribution of PDX tumors with cetuximab response data.
  • Fig. S5. Interrater reliability and variability between duplicate cores.
  • Fig. S6. Variability of EGFR:GRB2 PLA signal among EGFR mutant patients.
  • Fig. S7. Overall survival analysis with extended follow-up.

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Citation: M. A. Smith, R. Hall, K. Fisher, S. M. Haake, F. Khalil, M. B. Schabath, V. Vuaroqueaux, H.-H. Fiebig, S. Altiok, Y. A. Chen, E. B. Haura, Annotation of human cancers with EGFR signaling–associated protein complexes using proximity ligation assays. Sci. Signal. 8, ra4 (2015).

© 2014 American Association for the Advancement of Science