Supplementary Materials

Supplementary Materials for:

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression

Juliet Rashidian, Erwan Le Scolan, Xiaodan Ji, Qingwei Zhu, Melinda M. Mulvihill, Daniel Nomura, Kunxin Luo*

*Corresponding author. E-mail: kluo{at}berkeley.edu

This PDF file includes:

  • Fig. S1. Ski specifically interacts with Hippo signaling components to inhibit TAZ transcriptional activity.
  • Fig. S2. Ski interacts with the Hippo pathway and inhibits TAZ independently of its antagonism of TGF-β/Smad signaling.
  • Fig. S3. Multiple shSki MCF10A clones all displayed increased acinar size and cell mobility.
  • Fig. S4. Ski suppressed YAP/TAZ signaling by promoting their phosphorylation by Lats2.
  • Fig. S5. Ski-induced TAZ degradation is not mediated by the β-TrCP E3 ligase.

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Technical Details

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Proteomic analysis of Ski-associated proteins.

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Citation: J. Rashidian, E. Le Scolan, X. Ji, Q. Zhu, M. M. Mulvihill, D. Nomura, K. Luo, Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. Sci. Signal. 8, ra14 (2015).

© 2015 American Association for the Advancement of Science