Supplementary Materials for:

Interleukin-10–producing CD5⁺ B cells inhibit mast cells during immunoglobulin E–mediated allergic responses

Hyuk Soon Kim, A-Ram Kim, Do Kyun Kim, Hyun Woo Kim, Young Hwan Park, Geun Hyo Jang, Bokyung Kim, Yeong Min Park, Jueng Soo You, Hyung Sik Kim, Michael A. Beaven, Young Mi Kim, Wahn Soo Choi*

*Corresponding author. E-mail: wahnchoi{at}kku.ac.kr

This PDF file includes:

• Fig. S1. Analysis of the population of IL-10–producing CD5⁺ B cells involved in PSA.
• Fig. S2. Characterization of CD5⁺ B cells in IL-10^−/− mice and of IL-10–producing B cells stimulated by mast cells.
• Fig. S3. Analysis of the production of IL-10 by B cells, mast cells, and various tissue-derived CD5⁺ B cells.
• Fig. S4. The CD40-CD40L interaction is critical for mast cell–mediated IL-10 production by B cells.
• Fig. S5. IL-10 reduces the abundances of several critical signaling molecules in mast cells.

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Citation: H. S. Kim, A.-R. Kim, D. K. Kim, H. W. Kim, Y. H. Park, G. H. Jang, B. Kim, Y. M. Park, J. S. You, H. S. Kim, M. A. Beaven, Y. M. Kim, W. S. Choi, Interleukin-10–producing CD5⁺ B cells inhibit mast cells during immunoglobulin E–mediated allergic responses. Sci. Signal. 8, ra28 (2015).

© 2015 American Association for the Advancement of Science