Supplementary Materials

Supplementary Materials for:

HER2-mTOR signaling–driven breast cancer cells require ER-associated degradation to survive

Navneet Singh, Rashika Joshi, Kakajan Komurov*

*Corresponding author. E-mail: kakajan.komurov{at}cchmc.org

This PDF file includes:

  • Fig. S1. Select pathways that are overexpressed in HER2+ breast cancers.
  • Fig. S2. ERAD gene expression is not regulated by HER2.
  • Fig. S3. HER2+ breast cancer cells are selectively addicted to ERAD.
  • Fig. S4. Some ERAD genes are selectively acquired in HER2+ cells.
  • Fig. S5. Reversal of Eeyarestatin-induced proteotoxic ER stress in BT474 cells with lapatinib.
  • Fig. S6. HER2 overexpression does not sensitize MCF10A cells to DBeQ or NMS-873.
  • Fig. S7. JNK pathway is selectively repressed in HER2+ breast cancers.
  • Fig. S8. Justification of cutoff points for HER2+ and HER2 populations.
  • Legend for table S1

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). The tEXP, tCN, treg, tCOX+, and tCOX− values of genes for the TCGA, METABRIC, and CCLE data sets.

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Citation: N. Singh, R. Joshi, K. Komurov, HER2-mTOR signaling–driven breast cancer cells require ER-associated degradation to survive. Sci. Signal. 8, ra52 (2015).

© 2015 American Association for the Advancement of Science