Supplementary Materials

Supplementary Materials for:

Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation

Kevin Wilhelmsen,* Fengyun Xu, Katherine Farrar, Alphonso Tran, Samira Khakpour, Shirin Sundar, Arun Prakash, Jinhua Wang, Nathanael S. Gray, Judith Hellman

*Corresponding author. E-mail: wilhelmsenk{at}anesthesia.ucsf.edu

This PDF file includes:

  • Fig. S1. Domain organization of ERK5.
  • Fig. S2. XMD8-92, XMD17-109, and BIX02189 have no substantial effects on cell viability.
  • Fig. S3. The ERK5 inhibitor XMD8-92 reduces the amounts of proinflammatory cytokines secreted by HMVEC-lung cells when it is added before or after they are treated with LPS.
  • Fig. S4. MEK5 promotes the binding of neutrophils to activated ECs.
  • Fig. S5. ERK5 promotes the secretion of CCL2 and enhances PAI-1 activity in mice 24 hours after they are challenged with LPS.

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Citation: K. Wilhelmsen, F. Xu, K. Farrar, A. Tran, S. Khakpour, S. Sundar, A. Prakash, J. Wang, N. S. Gray, J. Hellman, Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation. Sci. Signal. 8, ra86 (2015).

© 2015 American Association for the Advancement of Science