Supplementary Materials

Supplementary Materials for:

The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development

Wai W. Lin, Zuoan Yi, Laura L. Stunz, Christian J. Maine, Linda A. Sherman, Gail A. Bishop*

*Corresponding author. E-mail: gail-bishop{at}uiowa.edu

This PDF file includes:

  • Fig. S1. The increase in the number of B cells caused by TRAF3 deficiency is independent of IL-6.
  • Fig. S2. Loss of TRAF3 in B cells does not alter the amounts of serum IL-6 in mice.
  • Fig. S3. Loss of TRAF3 does not affect IL-6R abundance on B cells.
  • Fig. S4. TRAF3 is not required for the IL-21–dependent activation of STAT3.
  • Fig. S5. TCPTP does not associate with Jak1 in B cells in response to IL-6.
  • Fig. S6. PTPN22-deficient B cells do not show enhanced PC differentiation in vitro in response to LPS and IL-6.

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Citation: W. W. Lin, Z. Yi, L. L. Stunz, C. J. Maine, L. A. Sherman, G. A. Bishop, The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development. Sci. Signal. 8, ra88 (2015).

© 2015 American Association for the Advancement of Science