Supplementary Materials

Supplementary Materials for:

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

Fengyuan Tang,* Jason Gill, Xenia Ficht, Thomas Barthlott, Hauke Cornils, Debora Schmitz-Rohmer, Debby Hynx, Dawang Zhou, Lei Zhang, Gongda Xue, Michal Grzmil, Zhongzhou Yang, Alexander Hergovich, Georg A. Hollaender, Jens V. Stein, Brian A. Hemmings, Patrick Matthias*

*Corresponding author. E-mail: patrick.matthias{at}fmi.ch (P.M.); fengyuan.tang{at}fmi.ch (F.T.)

This PDF file includes:

  • Fig. S1. Analysis of T cell apoptosis, proliferation, and T cell subsets in wild-type and Ndr DKO mice.
  • Fig. S2. Analysis of thymocyte proliferation and measurement of body and spleen weights of wild-type and Ndr DKO mice.
  • Fig. S3. Loss of NDRs results in the accumulation of mature SP thymocytes in the perivascular space of the thymus.
  • Fig. S4. Loss of NDRs does not impair the homing of naïve T cells to lymphoid organs.
  • Fig. S5. Biochemical analysis of MST-NDR signaling in T cells.

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Citation: F. Tang, J. Gill, X. Ficht, T. Barthlott, H. Cornils, D. Schmitz-Rohmer, D. Hynx, D. Zhou, L. Zhang, G. Xue, M. Grzmil, Z. Yang, A. Hergovich, G. A. Hollaender, J. V. Stein, B. A. Hemmings, P. Matthias, The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility. Sci. Signal. 8, ra100 (2015).

© 2015 American Association for the Advancement of Science