Supplementary Materials

Supplementary Materials for:

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1

Huabing Zhang, Sadeesh K. Ramakrishnan, Daniel Triner, Brook Centofanti, Dhiman Maitra, Balázs Győrffy, Judith S. Sebolt-Leopold, Michael K. Dame, James Varani, Dean E. Brenner, Eric R. Fearon, M. Bishr Omary, Yatrik M. Shah*

*Corresponding author. E-mail: shahy{at}umich.edu

This PDF file includes:

  • Fig. S1. YAP1 signaling is activated in human colon cancer cell lines and tissues.
  • Fig. S2. VP treatment does not induce toxicity in normal tissues.
  • Fig. S3. VP treatment decreases growth in CT-26 xenograft model and colon cancer cell lines.
  • Fig. S4. VP treatment inhibits STAT3 signaling.
  • Fig. S5. The growth inhibitory effect of VP is YAP1-independent.
  • Fig. S6. The growth inhibitory effect of VP is associated with oligomerization of proteins.
  • Fig. S7. Hypoxia and nutrient deprivation impair clearance of VP-induced protein oligomers.
  • Fig. S8. Activating autophagic and proteasomal pathways partially clears protein oligomers.
  • Legend for table S1
  • Table S2. List of primers.

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Technical Details

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Proteins that are oligomerized in response to VP.

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Citation: H. Zhang, S. K. Ramakrishnan, D. Triner, B. Centofanti, D. Maitra, B. Győrffy, J. S. Sebolt-Leopold, M. K. Dame, J. Varani, D. E. Brenner, E. R. Fearon, M. B. Omary, Y. M. Shah, Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1. Sci. Signal. 8, ra98 (2015).

© 2015 American Association for the Advancement of Science