Supplementary Materials

Supplementary Materials for:

Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis

Archana Jha, Ashish K. Singh, Petra Weissgerber, Marc Freichel, Veit Flockerzi, Richard A. Flavell, Mithilesh K. Jha*

*Corresponding author. E-mail: mkjha98{at}gmail.com

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  • Fig. S1. Cacnb2Cre/− mice have reduced numbers and proportions of peripheral T cells.
  • Fig. S2. DN thymocyte populations from Cacnb2Cre/− mice have an altered cell surface expression of CD5, but not CD24.
  • Fig. S3. Thymocytes from Cacnb2Cre/− mice exhibit defective proliferation.
  • Fig. S4. Cacnb2fl/fl effector T cells expressing Cre-encoding retrovirus show reduced production of IFN-γ.
  • Fig. S5. Cav1-deficient mice have normal percentages of thymocytes.
  • Fig. S6. Effect of the blockade of Cav1 channels on IL-2 production by mouse and human CD4+ T cells.
  • Fig. S7. Blockade of Cav1 channels impairs the expression of Nfatc3 in thymocytes.

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Citation: A. Jha, A. K. Singh, P. Weissgerber, M. Freichel, V. Flockerzi, R. A. Flavell, M. K. Jha, Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis. Sci. Signal. 8, ra103 (2015).

© 2015 American Association for the Advancement of Science