Supplementary Materials

Supplementary Materials for:

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake

Jonathan W. Haskins, Shannon Zhang, Robert E. Means, Joanne K. Kelleher, Gary W. Cline, Alberto Canfrán-Duque, Yajaira Suárez, David F. Stern*

*Corresponding author. E-mail: df.stern{at}yale.edu

This PDF file includes:

  • Fig. S1. Gene lists for cholesterol/SREBP enrichment in the ERBB4 ICD data set.
  • Fig. S2. Fatty acid synthesis genes in the ERBB4 ICD data set.
  • Fig. S3. NRG1 transcriptionally activates expression of SREBP-regulated genes and induces SREBP-2 cleavage.
  • Fig. S4. PF-429242 reduces SREBP-2 cleavage and does not inhibit ERBB4 phosphorylation.
  • Fig. S5. Impact of NRG1 and PMA on cleavage of ERBB4 juxtamembrane isoforms JM-a and JM-b.
  • Fig. S6. Regulation of cholesterogenic gene mRNA and HMGCR protein by EGF and NRG1 in MCF10A cells.
  • Table S1. Determination of cholesterol biosynthesis by ISA.

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Citation: J. W. Haskins, S. Zhang, R. E. Means, J. K. Kelleher, G.W. Cline, A. Canfrán-Duque, Y. Suárez, D. F. Stern, Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake. Sci. Signal. 8, ra111 (2015).

© 2015 American Association for the Advancement of Science