Supplementary Materials

Supplementary Materials for:

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

Maitea Guridi, Lionel A. Tintignac, Shuo Lin, Barbara Kupr, Perrine Castets, Markus A. Rüegg*

*Corresponding author. E-mail: markus-a.ruegg{at}unibas.ch

This PDF file includes:

  • Fig. S1. TSCmKO mice do not show overt behavioral changes.
  • Fig. S2. Higher plasma concentrations of free fatty acids in TSCmKO mice.
  • Fig. S3. TSCmKO mice do not show changes in the expression of genes encoding enzymes involved in glycolysis.
  • Fig. S4. FGF21 abundance in muscle is increased in TSCmKO mice.
  • Fig. S5. FGF21 in TSCmKO mice is not induced upon autophagy impairment or mitochondrial dysfunction.
  • Fig. S6. FGF21 blockade does not alter plasma insulin concentration in TSCmKO mice or metabolism in control mice.
  • Table S1. Weight and size analysis in 10- and 40-week-old mice.
  • Table S2. COBAS plasma analysis of 10-week-old mice.
  • Table S3. Primers used for quantitative polymerase chain reaction.

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Citation: M. Guridi, L. A. Tintignac, S. Lin, B. Kupr, P. Castets, M. A. Rüegg, Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21. Sci. Signal. 8, ra113 (2015).

© 2015 American Association for the Advancement of Science