Supplementary Materials

Supplementary Materials for:

Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas

Lei Zhang, Soumi Kundu, Tjerk Feenstra, Xiujuan Li, Chuan Jin, Liisi Laaniste, Tamador Elsir Abu El Hassan, K. Elisabet Ohlin, Di Yu, Tommie Olofsson, Anna-Karin Olsson, Fredrik Pontén, Peetra U. Magnusson, Karin Forsberg Nilsson, Magnus Essand, Anja Smits, Lothar C. Dieterich, Anna Dimberg*

*Corresponding author. E-mail: anna.dimberg{at}igp.uu.se

This PDF file includes:

  • Fig. S1. Survival of grade II to III astrocytoma and glioblastoma patients with low and high PTN mRNA abundance.
  • Fig. S2. Expression of PTN in GL261 and CT-2A murine glioma cells does not affect tumor cell proliferation in vitro.
  • Fig. S3. PTN expression does not affect tumor cell apoptosis in orthotopic GL261 tumors.
  • Fig. S4. ALK is found in GL261 tumor vasculature.
  • Fig. S5. PTN overexpression does not affect vascular permeability in GL261 tumors.
  • Fig. S6. PTN is not detectable in R1 ES cells until EBs are formed.
  • Table S1. Antibodies and staining reagents list.
  • Table S2. shRNA sequences.
  • Table S3. qPCR primers.

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Citation: L. Zhang, S. Kundu, T. Feenstra, X. Li, C. Jin, L. Laaniste, T. E. A. El Hassan, K. E. Ohlin, D. Yu, T. Olofsson, A.-K. Olsson, F. Pontén, P. U. Magnusson, K. F. Nilsson, M. Essand, A. Smits, L. C. Dieterich, A. Dimberg, Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas. Sci. Signal. 8, ra125 (2015).

© 2015 American Association for the Advancement of Science