Supplementary Materials

Supplementary Materials for:

Network-level effects of kinase inhibitors modulate TNF-α–induced apoptosis in the intestinal epithelium

Jessica J. Gierut, Levi B. Wood, Ken S. Lau, Yi-Jang Lin, Casie Genetti, Ahmed A. Samatar, Douglas A. Lauffenburger, Kevin M. Haigis*

*Corresponding author. E-mail: khaigis{at}bidmc.harvard.edu

This PDF file includes:

  • Fig. S1. Chemical structures of phosphoprotein signaling inhibitors.
  • Fig. S2. MAPK pathway inhibitors alter the TNF-α–induced flux through multiple cellular signaling pathways.
  • Fig. S3. D-PLSR analysis of the phosphoprotein signaling network.
  • Fig. S4. SOM analysis of the phosphoprotein signaling network.
  • Fig. S5. Influence of the Akt pathway inhibitors BEZ235 and MK-2206 on CC3 abundance and phosphoprotein signaling.

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Citation: J. J. Gierut, L. B. Wood, K. S. Lau, Y.-J. Lin, C. Genetti, A. A. Samatar, D. A. Lauffenburger, K. M. Haigis, Network-level effects of kinase inhibitors modulate TNF-α–induced apoptosis in the intestinal epithelium. Sci. Signal. 8, ra129 (2015).

© 2015 American Association for the Advancement of Science