Supplementary Materials

Supplementary Materials for:

Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect

Rifdat Aoidi, Annie Maltais, Jean Charron*

*Corresponding author. E-mail: jean.charron{at}crhdq.ulaval.ca

This PDF file includes:

  • Fig. S1. Targeted replacement of Mek1 gene with cDNA encoding Myc-tagged MEK1 or Myc-tagged MEK2.
  • Fig. S2. Mek12/− mutants showed intrauterine growth restriction.
  • Fig. S3. Mek12 and Mek2+ alleles produce less Myc-tagged MEK2 and endogenous MEK2, respectively, when compared to MEK1 produced by the Mek1+ wild-type allele.
  • Table S1. Viability of Mek11/1, Mek11neo2/1neo2, Mek12/2, and Mek12/− embryos and mice at various ages.
  • Table S2. A MEK1 and MEK2 protein dosage model in placenta development.

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Citation: R. Aoidi, A. Maltais, J. Charron, Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect. Sci. Signal. 9, ra9 (2016).

© 2016 American Association for the Advancement of Science