Supplementary Materials

Supplementary Materials for:

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis

Brian J. DeBosch,* Monique R. Heitmeier, Allyson L. Mayer, Cassandra B. Higgins, Jan R. Crowley, Thomas E. Kraft, Maggie Chi, Elizabeth P. Newberry, Zhouji Chen, Brian N. Finck, Nicholas O. Davidson, Kevin E. Yarasheski, Paul W. Hruz, Kelle H. Moley

*Corresponding author. E-mail: debosch_b{at}kids.wustl.edu

This PDF file includes:

  • Fig. S1. The effect of the HIV protease inhibitor lopinavir on 2-DG uptake, AMPK activation, and autophagic flux.
  • Fig. S2. The effect of sucrose on primary hepatocyte autophagy and AMPK signaling.
  • Fig. S3. The effect of trehalose on LC3B-II accumulation and triglyceride accumulation in HepG2 cells.
  • Table S1. Absolute mRNA copy numbers in the 293 GLUT expression system.

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Citation: B. J. DeBosch, M. R. Heitmeier, A. L. Mayer, C. B. Higgins, J. R. Crowley, T. E. Kraft, M. Chi, E. P. Newberry, Z. Chen, B. N. Finck, N. O. Davidson, K. E. Yarasheski, P. W. Hruz, K. H. Moley, Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci. Signal. 9, ra21 (2016).

© 2016 American Association for the Advancement of Science