Supplementary Materials

Supplementary Materials for:

A peptide of the RGS domain of GRK2 binds and inhibits Gαq to suppress pathological cardiac hypertrophy and dysfunction

Sarah M. Schumacher, Erhe Gao, Maya Cohen, Melissa Lieu, J. Kurt Chuprun, Walter J. Koch*

*Corresponding author. E-mail: walter.koch{at}temple.edu

This PDF file includes:

  • Fig. S1. TgβARKrgs mice exhibit a similar decrease in cardiac hypertrophy as TgGqI mice after TAC.
  • Fig. S2. Chronic pressure overload–induced heart failure is inhibited by cardiac βARKrgs expression.
  • Fig. S3. Molecular markers of left ventricular dysfunction are reduced in TgβARKrgs and TgGqI mice but not in TgβARKct mice.
  • Fig. S4. Left ventricular structural remodeling is inhibited in TgβARKrgs mice.
  • Fig. S5. The βARKrgs peptide interacts with endogenous Gαq in the heart.

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Citation: S. M. Schumacher, E. Gao, M. Cohen, M. Lieu, J. K. Chuprun, W. J. Koch, A peptide of the RGS domain of GRK2 binds and inhibits Gαq to suppress pathological cardiac hypertrophy and dysfunction. Sci. Signal. 9, ra30 (2016).

© 2016 American Association for the Advancement of Science