Supplementary Materials

Supplementary Materials for:

Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis

Jennifer C. Tudor, Emily J. Davis, Lucia Peixoto, Mathieu E. Wimmer, Erik van Tilborg, Alan J. Park, Shane G. Poplawski, Caroline W. Chung, Robbert Havekes, Jiayan Huang, Evelina Gatti, Philippe Pierre, Ted Abel*

*Corresponding author. Email: abele{at}sas.upenn.edu

This PDF file includes:

  • Fig. S1. Schematic showing the mechanism of attenuated translation in the hippocampus caused by sleep deprivation.
  • Fig. S2. Control immunoblots of hippocampal extracts treated with rabbit IgG.
  • Fig. S3. The abundance of phosphorylated TSC2 does not change after 5 hours of sleep deprivation.
  • Fig. S4. Five hours of sleep deprivation reduces the abundance of phosphorylated 4EBP2, which rebounds after 2.5 hours of recovery sleep.
  • Fig. S5. Abundance of phosphorylated eIF2α does not change after 5 hours of sleep deprivation.

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Citation: J. C. Tudor, E. J. Davis, L. Peixoto, M. E. Wimmer, E. van Tilborg, A. J. Park, S. G. Poplawski, C. W. Chung, R. Havekes, J. Huang, E. Gatti, P. Pierre, T. Abel, Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis. Sci. Signal. 9, ra41 (2016).

© 2016 American Association for the Advancement of Science