Supplementary Materials

Supplementary Materials for:

PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress

Céline Philippe, Alexandre Dubrac, Cathy Quelen, Aurore Desquesnes, Loic Van Den Berghe, Christèle Ségura, Thomas Filleron, Stéphane Pyronnet, Hervé Prats, Pierre Brousset, Christian Touriol

*Corresponding author. Email: christian.touriol{at}inserm.fr

This PDF file includes:

  • Fig. S1. Effect of ER stress on cap- and IRES-dependent translation in the lungs and kidneys.
  • Fig. S2. VEGF and FGF-2 IRES activities are stimulated by tunicamycin in a dose-dependent
    manner.
  • Fig. S3. ER stress inducers stimulate VEGF and FGF-2 IRES activities in a time-dependent
    manner.
  • Fig. S4. Effect of eIF2α phosphorylation on cap-dependent translation and translation through VEGF and FGF-2 IRESs.
  • Fig. S5. Effect of pharmacological activation and inhibition of PERK on the translational activation of the IRESs for angiogenic growth factor mRNAs.
  • Table S1. Oligonucleotide sequences.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 1.39 MB


Citation: C. Philippe, A. Dubrac, C. Quelen, A. Desquesnes, L. Van Den Berghe,
C. Ségura, T. Filleron, S. Pyronnet, H. Prats, P. Brousset, C. Touriol, PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress. Sci. Signal. 9, ra44 (2016).

© 2016 American Association for the Advancement of Science