Supplementary Materials

Supplementary Materials for:

Notch signaling in group 3 innate lymphoid cells modulates their plasticity

Sylvestre Chea, Thibaut Perchet, Maxime Petit, Thomas Verrier, Delphine Guy-Grand, Elena-Gaia Banchi, Christian A. J. Vosshenrich, James P. Di Santo, Ana Cumano, Rachel Golub*

*Corresponding author. Email: rachel.golub{at}pasteur.fr

This PDF file includes:

  • Fig. S1. Rbpj is efficiently deleted in IL-7Rα+ CLPs by Cre recombinase.
  • Fig. S2. Notch2 signaling is specifically required for both NCR+ and NCR ILC3s.
  • Fig. S3. Analysis of cytokine secretion and receptors in Il7rCre/+Rbpjfl/+ mice and
    Il7rCre/+Rbpjfl/fl mice.
  • Fig. S4. Expression of Gata3 and Il7ra in ILC3 subsets in the presence or absence of
    Notch signaling.
  • Fig. S5. The expression of genes encoding proapoptotic proteins in ILC3 subsets is
    unchanged by the loss of Notch signaling.
  • Fig. S6. Analysis of ILC3 and ILC1 subsets in Ncr1Cre/+Rosa26NICD/+ mice.
  • Fig. S7. Analysis of transcription factors expressed in ILC3 and ILC1 subsets in
    Il7rCre/+ Rbpjfl/+ mice and Il7rCre/+Rbpjfl/fl mice.
  • Legend for table S1

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). P values for the differential expression of 92
    genes between the NCR+, CCR6+NCR, and CCR6NCR subsets of Il7rCre/+Rbpjfl/+
    mice and Il7rCre/+Rbpjfl/fl mice.

Citation: S. Chea, T. Perchet, M. Petit, T. Verrier, D. Guy-Grand, E.-G. Banchi,
C. A. J. Vosshenrich, J. P. Di Santo, A. Cumano, R. Golub, Notch signaling in group 3 innate lymphoid cells modulates their plasticity. Sci. Signal. 9, ra45 (2016).

© 2016 American Association for the Advancement of Science