Supplementary Materials

Supplementary Materials for:

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

Risa Kashima, Sougata Roy, Manuel Ascano, Veronica Martinez-Cerdeno, Jeanelle Ariza-Torres, Sunghwan Kim, Justin Louie, Yao Lu, Patricio Leyton, Kenneth D. Bloch, Thomas B. Kornberg, Paul J. Hagerman, Randi Hagerman, Giorgio Lagna, Akiko Hata*

*Corresponding author. Email: akiko.hata{at}ucsf.edu

This PDF file includes:

  • Fig. S1. Translational regulation of BMPR2 through the mRNA sequence encoding the CTD.
  • Fig. S2. FMRP binds BMPR2-CTDseq and suppresses translation.
  • Fig. S3. BMP4-SMAD1/5 signaling is increased, but TGFβ-SMAD2/3 signaling is not altered in FMR1-null cells.
  • Fig. S4. LIMK-i and LDN effectively inhibit LIMK1 and BMPR1 kinase activity in N1E cells.
  • Fig. S5. In vivo administration of LIMK-i inhibits phosphorylation of cofilin in mouse brain.
  • Table S1. qRT-PCR primers.
  • Table S2. RIP PCR primers.

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Citation: R. Kashima, S. Roy, M. Ascano, V. Martinez-Cerdeno, J. Ariza-Torres, S. Kim, J. Louie, Y. Lu, P. Leyton, K. D. Bloch, T. B. Kornberg, P. J. Hagerman, R. Hagerman, G. Lagna, A. Hata, Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome. Sci. Signal. 9, ra58 (2016).

© 2016 American Association for the Advancement of Science