Supplementary Materials

Supplementary Materials for:

Lipocalin 2 from macrophages stimulated by tumor cell–derived sphingosine-1-phosphate promotes lymphangiogenesis and tumor metastasis

Michaela Jung, Bilge Ören, Javier Mora, Christina Mertens, Sarah Dziumbla, Rüdiger Popp, Andreas Weigert, Nina Grossmann, Ingrid Fleming, Bernhard Brüne*

*Corresponding author. Email: b.bruene{at}biochem.uni-frankfurt.de

This PDF file includes:

  • Fig. S1. Tumor cell–derived LCN2 and expression of S1PR1, S1PR2, and S1PR4 in primary human macrophages.
  • Fig. S2. Knockdown efficiency of S1PR1, S1PR2, and S1PR4 in primary human macrophages.
  • Fig. S3. Effects of S1P on lymphangiogenesis in culture.
  • Fig. S4. Effect of tumor cell–derived LCN2 on LEC proliferation.
  • Fig. S5. Expression of lymphangiogenesis-associated genes in LECs.
  • Table S1. PCR primers.

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Citation: M. Jung, B. Ören, J. Mora, C. Mertens, S. Dziumbla, R. Popp, A. Weigert, N. Grossmann, I. Fleming, B. Brüne, Lipocalin 2 from macrophages stimulated by tumor cell–derived sphingosine-1-phosphate promotes lymphangiogenesis and tumor metastasis. Sci. Signal. 9, ra64 (2016).

© 2016 American Association for the Advancement of Science