Supplementary Materials for:

Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways

Bing Liu, Qian Liu, Lei Yang, Sucheendra K. Palaniappan, Ivet Bahar, P. S. Thiagarajan,* Jeak Ling Ding*

*Corresponding author. Email: thiagu{at}hms.harvard.edu (P.S.T.); dbsdjl{at}nus.edu.sg (J.L.D.)

This PDF file includes:

• Text
• Fig. S1. The reaction schemas for the TLR3 and TLR7 signaling networks.
• Fig. S2. Knockout simulation results.
• Fig. S3. Combinatorial knockout simulation results.
• Fig. S4. Analysis of the abundances of Il1a, Il10, and Csf3 mRNAs in response to in silico and empirical perturbation of the JAK-STAT pathway.
• Fig. S5. Incremental induction of Stat1 expression in BMDMs derived from Stat1^ind mice.
• Fig. S6. Analysis of the efficiency of knockdown of Stat1.
• Table S1. List of species and their initial concentrations.
• Table S2. List of parameters and their values.
• Reference (78)

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Citation: B. Liu, Q. Liu, L. Yang, S. K. Palaniappan, I. Bahar, P. S. Thiagarajan, J. L. Ding, Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways. Sci. Signal. 9, ra70 (2016).

© 2016 American Association for the Advancement of Science