Supplementary Materials

Supplementary Materials for:

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML

Isabel Morgado-Palacin, Amanda Day, Matilde Murga, Vanesa Lafarga, Marta Elena Anton, Anthony Tubbs, Hua-Tang Chen, Aysegul Ergan, Rhonda Anderson, Avinash Bhandoola, Kurt G. Pike, Bernard Barlaam, Elaine Cadogan, Xi Wang, Andrew J. Pierce, Chad Hubbard, Scott A. Armstrong, André Nussenzweig,* Oscar Fernandez-Capetillo*

*Corresponding author. Email: ofernandez{at}cnio.es (O.F.-C.); nussenza{at}mail.nih.gov (A.N.)

This PDF file includes:

  • Fig. S1. CHEK1 mRNA expression is highest in lymphomas and leukemias.
  • Fig. S2. Toxicity, replication stress, and DNA breakage induced by two distinct ATR inhibitors in AMLMLL cells.
  • Legends for movies S1 to S6

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). Control mice for the ATRi experiment with animals injected with AMLMLL cells after treatment with vehicle.
  • Movie S2 (.mov format). Mice injected with AMLMLL cells and treated with ATRi on the prevention protocol.
  • Movie S3 (.mov format). Mice injected with AMLMLL cells and treated with ATRi on the therapy protocol.
  • Movie S4 (.mov format). Control mice for the ATMi experiment with animals injected with AMLMLL cells after treatment with vehicle.
  • Movie S5 (.mov format). Mice injected with AMLMLL cells and treated with ATMi on the prevention protocol.
  • Movie S6 (.mov format). Mice injected with AMLMLL and treated with ATMi on the therapy protocol.

Citation: I. Morgado-Palacin, A. Day, M. Murga, V. Lafarga, M. E. Anton, A. Tubbs, H.-T. Chen, A. Ergan, R. Anderson, A. Bhandoola, K. G. Pike, B. Barlaam, E. Cadogan, X. Wang, A. J. Pierce, C. Hubbard, S. A. Armstrong, A. Nussenzweig, O. Fernandez-Capetillo, Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Sci. Signal. 9, ra91 (2016).

© 2016 American Association for the Advancement of Science