Supplementary Materials

Supplementary Materials for:

Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells

Haiyan S. Li, Chengwen Liu, Yichuan Xiao, Fuliang Chu, Xiaoxuan Liang, Weiyi Peng, Jianhua Hu, Sattva S. Neelapu, Shao-Cong Sun, Patrick Hwu, Stephanie S. Watowich*

*Corresponding author. Email: swatowic{at}mdanderson.org

This PDF file includes:

  • Fig. S1. Characterization and function of RV–GM-DCs and ID2–GM-DCs.
  • Fig. S2. Characterization of STAT3 signaling pathways.
  • Fig. S3. Regulation of Id2 by STAT3-activating cytokines in D2SC/1 cells.
  • Fig. S4. Phenotypic characterization of Stat3-sufficient and Stat3-deficient GM-DCs.
  • Fig. S5. RV–GM-DC and ID2–GM-DC cell surface phenotypes.
  • Fig. S6. Effects of ID2 in D2SC/1 cells and cytokine production in B16 melanoma tumors.
  • Fig. S7. MAPK activation in RV–GM-DCs and ID2–GM-DCs.
  • Fig. S8. Mononuclear cell infiltration in B16 melanomas upon GM-DC vaccination.
  • Table S1. Oligonucleotide sequences.

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Citation: H. S. Li, C. Liu, Y. Xiao, F. Chu, X. Liang, W. Peng, J. Hu, S. S. Neelapu, S.-C. Sun, P. Hwu, S. S. Watowich, Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Sci. Signal. 9, ra94 (2016).

© 2016 American Association for the Advancement of Science