Supplementary Materials

Supplementary Materials for:

Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus

Jing Ye, Hao Zhang, Wen He, Bibo Zhu, Dengyuan Zhou, Zheng Chen, Usama Ashraf, Yanming Wei, Ziduo Liu, Zhen F. Fu, Huanchun Chen, Shengbo Cao*

*Corresponding author. Email: sbcao{at}mail.hzau.edu.cn

This PDF file includes:

  • Fig. S1. Expression of inflammatory cytokines in JEV-infected U251 cells.
  • Fig. S2. Protein-protein interaction network constructed from the phosphoproteins regulated by JEV infection of U251 cells.
  • Fig. S3. Representative MS of phosphorylated peptides of AKT1, PRKACA, and TP53.
  • Legends for tables S1 to S8

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Quantification of phosphopeptides detected by LC-MS/MS.
  • Table S2 (Microsoft Excel format). Differentially regulated phosphopeptides in response to JEV infection.
  • Table S3 (Microsoft Excel format). GO and KEGG pathway analysis of the up-regulated phosphoproteome of JEV-infected U251 cells.
  • Table S4 (Microsoft Excel format). GO and KEGG pathway analysis of the down-regulated phosphoproteome of JEV-infected U251 cells.
  • Table S5 (Microsoft Excel format). Phosphoproteins in the interaction network of JEV-infected U251 cells.
  • Table S6 (Microsoft Excel format). Differentially regulated phosphoproteins that are shared between cells infected with JEV or WNV.
  • Table S7 (Microsoft Excel format). Prediction of JEV-responsive kinases by using the GPS.
  • Table S8 (Microsoft Excel format). Overrepresented motifs in the up-regulated phosphoproteins in JEV-infected cells.

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Citation: J. Ye, H. Zhang, W. He, B. Zhu, D. Zhou, Z. Chen, U. Ashraf, Y. Wei, Z. Liu, Z. F. Fu, H. Chen, S. Cao, Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus. Sci. Signal. 9, ra98 (2016).

© 2016 American Association for the Advancement of Science