Supplementary Materials

Supplementary Materials for:

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling

Claire Rutherford, Claire Speirs, Jamie J. L. Williams, Marie-Ann Ewart, Sarah J. Mancini, Simon A. Hawley, Christian Delles, Benoit Viollet, Ana P. Costa-Pereira, George S. Baillie, Ian P. Salt,* Timothy M. Palmer*

*Corresponding author. Email: t.palmer1{at}bradford.ac.uk (T.M.P.); ian.salt{at}glasgow.ac.uk (I.P.S.)

This PDF file includes:

  • Fig. S1. AMPK-mediated inhibition of STAT3 phosphorylation in HUVECs.
  • Fig. S2. AMPK-mediated inhibition of sIL-6Rα/IL-6–stimulated SOCS3 and CEBPD mRNA induction.
  • Fig. S3. Contributions of JAK1, JAK2, and Tyk2 in mediating sIL-6Rα/IL-6–mediated STAT3 phosphorylation in HUVECs.
  • Fig. S4. Specific interaction of JAK1 with 14-3-3ξ and 14-3-3τ.

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Citation: C. Rutherford, C. Speirs, J. J. L. Williams, M.-A. Ewart, S. J. Mancini, S. A. Hawley, C. Delles, B. Viollet, A. P. Costa-Pereira, G. S. Baillie, I. P. Salt, T. M. Palmer, Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Sci. Signal. 9, ra109 (2016).

© 2016 American Association for the Advancement of Science