Supplementary Materials

Supplementary Materials for:

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

Avital Licht-Murava, Rom Paz, Lilach Vaks, Limor Avrahami, Batya Plotkin, Miriam Eisenstein, Hagit Eldar-Finkelman*

*Corresponding author. Email: heldar{at}post.tau.ac.il

This PDF file includes:

  • Fig. S1. RMSDs along the last 50 ns of each trajectory, calculated for the Cα atoms of loop 63 to 68, loop 89 to 95, or the peptide, after superposition of the restrained Cα atoms of GSK-3β.
  • Fig. S2. Time dependence of the distances between selected residues in the GSK-3β/ATP/2Mg2+/L807 complex.
  • Fig. S3. Time dependence of the distances between selected residues in the GSK-3β/ADP/2Mg2+/DpL807 complex.
  • Table S1. Selectivity of L807mts toward a panel of protein kinases.
  • Table S2. L807mts toxicology screening.

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Citation: A. Licht-Murava, R. Paz, L. Vaks, L. Avrahami, B. Plotkin, M. Eisenstein, H. Eldar-Finkelman, A unique type of GSK-3 inhibitor brings new opportunities to the clinic. Sci. Signal. 9, ra110 (2016).

© 2016 American Association for the Advancement of Science