Supplementary Materials

Supplementary Materials for:

Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus

Iwona A. Buskiewicz,* Theresa Montgomery, Elizabeth C. Yasewicz, Sally A. Huber, Michael P. Murphy, Richard C. Hartley, Ryan Kelly, Mary K. Crow, Andras Perl, Ralph C. Budd, Andreas Koenig*

*Corresponding author. Email: akoenig{at}uvm.edu (A.K.); ibuskiew{at}uvm.edu (I.A.B.)

This PDF file includes:

  • Fig. S1. Measurement of mROS, mitochondrial mass, and mitochondrial phenotype.
  • Fig. S2. MAVS oligomers are not artificially formed during sample processing, homogenization, or lysis, and IL-6 production in the presence of ROS is independent of RIG-I helicases.
  • Fig. S3. MAVS oligomers are not artificially formed during the processing, homogenization, or lysis of SLE patient samples.
  • Fig. S4. Analysis of mitochondrial respiration in PBMC subsets.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 884 KB


Citation: I. A. Buskiewicz, T. Montgomery, E. C. Yasewicz, S. A. Huber, M. P. Murphy, R. C. Hartley, R. Kelly, M. K. Crow, A. Perl, R. C. Budd, A. Koenig, Reactive oxygen species induce virusindependent MAVS oligomerization in systemic lupus erythematosus. Sci. Signal. 9, ra115 (2016).

© 2016 American Association for the Advancement of Science