Supplementary Materials

Supplementary Materials for:

A TGFβ–miR-182–BRCA1 axis controls the mammary differentiation hierarchy

Haydeliz Martinez-Ruiz, Irineu Illa-Bochaca, Coral Omene, Douglas Hanniford, Qi Liu, Eva Hernando, Mary Helen Barcellos-Hoff*

*Corresponding author. Email: mary.barcellos-hoff{at}

This PDF file includes:

  • Fig. S1. Tgfb1 WT and HT mammary serial transplantation capacity.
  • Fig. S2. Representative FACS profiles of Tgfb1 WT and HT MECs.
  • Fig. S3. Representative phase-contrast images of mammospheres.
  • Fig. S4. p-SMAD2 intensity in mammary epithelium of mice treated with TGFβ neutralizing antibody.
  • Fig. S5. Representative immunoblot for Fig. 4.
  • Fig. S6. Analysis of miR-181.
  • Fig. S7. Analysis of miR-146.
  • Fig. S8. Effects of miRZip-182 expression in MECs.
  • Table S1. Primers.

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Citation: H. Martinez-Ruiz, I. Illa-Bochaca, C. Omene, D. Hanniford, Q. Liu, E. Hernando, M. H. Barcellos-Hoff, A TGFβ–miR-182–BRCA1 axis controls the mammary differentiation hierarchy. Sci. Signal. 9, ra118 (2016).

© 2016 American Association for the Advancement of Science