Supplementary Materials

Supplementary Materials for:

Late-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages

Budhaditya Chatterjee, Balaji Banoth, Tapas Mukherjee, Nandaraj Taye, Bharath Vijayaragavan, Samit Chattopadhyay, James Gomes, Soumen Basak*

*Corresponding author. Email: sobasak{at}nii.ac.in

This PDF file includes:

  • Detailed description of variance-based global sensitivity analysis
  • Fig. S1. NF-κB signaling in fibroblasts and macrophages.
  • Fig. S2. Constitutive expression of Nfkb2 in various cell lines.
  • Fig. S3. Variance-based global sensitivity analysis of NF-κB Systems Model v1.0.
  • Fig. S4. The enhanced rate of RelA-responsive IκBα synthesis is inversely correlated with pathway cross-talk.
  • Fig. S5. Smar1 inhibits RelA-induced Nfkbia expression during LPS signaling.
  • Table S1. List of parameter groups and kinetic rate constants.
  • Table S2. List of notations used in the model to describe different biochemical species.
  • References (4649)

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 1.92 MB


Citation: B. Chatterjee, B. Banoth, T. Mukherjee, N. Taye, B. Vijayaragavan, S. Chattopadhyay, J. Gomes, S. Basak, Late-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages. Sci. Signal. 9, ra120 (2016).

© 2016 American Association for the Advancement of Science