Supplementary Materials

Supplementary Materials for:

Synergistic regulation of serotonin and opioid signaling contribute to pain insensitivity in Nav1.7 knockout mice

Jörg Isensee,* Leonhardt Krahé, Katharina Moeller, Vanessa Pereira, Jane E. Sexton, Xiaohui Sun, Edward Emery, John N. Wood, Tim Hucho*

*Corresponding author. Email: joerg.isensee{at}uk-koeln.de (J.I.); tim.hucho{at}uk-koeln.de (T.H.)

This PDF file includes:

  • Fig. S1. Experimental outline for analyzing Gs- and Gi-coupled GPCR signaling in sensory neurons by HCS microscopy.
  • Fig. S2. Opioids inhibit PGI2- and Fsk-induced pRII increase in rat sensory neurons.
  • Fig. S3. Enhanced efficacy of opioids to inhibit the induction of pRII by 5-HT or Fsk in Nav1.7-deficient sensory neurons.

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Citation: J. Isensee, L. Krahé, K. Moeller, V. Pereira, J. E. Sexton, X. Sun, E. Emery, J. N. Wood, T. Hucho, Synergistic regulation of serotonin and opioid signaling contribute to pain insensitivity in Nav1.7 knockout mice. Sci. Signal. 10, eaah4874 (2017).

© 2017 American Association for the Advancement of Science