Supplementary Materials

Supplementary Materials for:

The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer

Robert M. Gemmill, Patrick Nasarre, Joyce Nair-Menon, Federico Cappuzzo, Lorenza Landi, Armida D'Incecco, Hidetaka Uramoto, Takeshi Yoshida, Eric B. Haura, Kent Armeson, Harry A. Drabkin*

*Corresponding author. Email: drabkin{at}musc.edu

This PDF file includes:

  • Fig. S1. Sequence alignments of NRP2b with NRP2a and NRP1.
  • Fig. S2. Development and validation of NRP2 isoform-specific shRNAs.
  • Fig. S3. Development and validation of NRP2b-specific antibody 9080.
  • Fig. S4. NRP2b inhibits proliferation in vitro and in vivo.
  • Fig. S5. Immunohistochemical staining of human lung tumors with NRP2 antibodies.
  • Table S1. Patient characteristics and histology of the 436-case TMA.
  • Table S2. Patient characteristics and histology of the 110-case BioMax Inc. TMA.
  • Table S3. Secretome analysis of TGFβ-exposed H358 cells.
  • Table S4. Oligonucleotide sequences used in this study.

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Citation: R. M. Gemmill, P. Nasarre, J. Nair-Menon, F. Cappuzzo, L. Landi, A. D'Incecco, H. Uramoto, T. Yoshida, E. B. Haura, K. Armeson, H. A. Drabkin, The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer. Sci. Signal. 10, eaag0528 (2017).

© 2017 American Association for the Advancement of Science