Supplementary Materials

Supplementary Materials for:

Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel CaV1.2 by the β2-adrenergic receptor in neurons

Hai Qian, Tommaso Patriarchi, Jennifer L. Price, Lucas Matt, Boram Lee, Madeline Nieves-Cintrón, Olivia R. Buonarati, Dhrubajyoti Chowdhury, Evanthia Nanou, Matthew A. Nystoriak, William A. Catterall, Montatip Poomvanicha, Franz Hofmann, Manuel F. Navedo,* Johannes W. Hell*

*Corresponding author. Email: mfnavedo{at}ucdavis.edu (M.F.N.); jwhell{at}ucdavis.edu (J.W.H.)

This PDF file includes:

  • Fig. S1. β2AR stimulation increases L-type currents in CA1 neurons.
  • Fig. S2. βAR stimulation increases L-type currents in cardiomyocytes from S1928A KI mice.
  • Fig. S3. β2AR controls phosphorylation of Cav1.2 in CA1.
  • Fig. S4. Basal synaptic transmission is normal in S1928A KI mice.
  • Fig. S5. PTT-LTP does not require phosphorylation of α11.2 on Ser1700 or Thr1704.
  • Fig. S6. Basal synaptic transmission is normal in STAA KI mice.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 1.74 MB


Citation: H. Qian, T. Patriarchi, J. L. Price, L. Matt, B. Lee, M. Nieves-Cintron, O. R. Buonarati, D. Chowdhury, E. Nanou, M. A. Nystoriak, W. A. Catterall, M. Poomvanicha, F. Hofmann, M. F. Navedo, J. W. Hell, Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons. Sci. Signal. 10, eaaf9659 (2017).

© 2017 American Association for the Advancement of Science