Supplementary Materials

Supplementary Materials for:

The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo

Caini Liu, Liang Zhu, Koichi Fukuda, Suidong Ouyang, Xing Chen, Chenhui Wang, Cun-jin Zhang, Bradley Martin, Chunfang Gu, Luke Qin, Suguna Rachakonda, Mark Aronica, Jun Qin,* Xiaoxia Li*

*Corresponding author. Email: qinj{at}ccf.org (J.Q.); lix{at}ccf.org (X.L.)

This PDF file includes:

  • Fig. S1. A18 binds directly to IL-17RA.
  • Fig. S2. A18 specifically inhibits IL-17A–induced gene expression.
  • Fig. S3. A18 alleviates TH17 cell–mediated, but not TH1 cell–mediated, EAE in mice.
  • Fig. S4. HFD-induced asthma is attenuated in IL-17RC–deficient mice.
  • Fig. S5. HDM- and CFA-induced asthma is alleviated in IL-17RC–deficient mice.
  • Fig. S6. Analysis of the C6–C3–C6 flavonoid skeleton and of the hydroxyl groups of A18 that are critical to inhibit IL-17A signaling.

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Citation: C. Liu, L. Zhu, K. Fukuda, S. Ouyang, X. Chen, C. Wang, C.-j. Zhang, B. Martin, C. Gu, L. Qin, S. Rachakonda, M. Aronica, J. Qin, X. Li, The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo. Sci. Signal. 10, eaaf8823 (2017).

© 2017 American Association for the Advancement of Science