Supplementary Materials

Supplementary Materials for:

Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

Camila C. Portugal,* Renato Socodato, Teresa Canedo, Cátia M. Silva, Tânia Martins, Vivian S. M. Coreixas, Erick C. Loiola, Burkhard Gess, Dominik Röhr, Ana R. Santiago, Peter Young, Richard D. Minshall, Roberto Paes-de-Carvalho, António F. Ambrósio, João B. Relvas*

*Corresponding author. Email: jrelvas{at}ibmc.up.pt (J.B.R.); camila.portugal{at}ibmc.up.pt (C.C.P.)

This PDF file includes:

  • Fig. S1. SVCT2 photoconversion in microglia.
  • Fig. S2. SVCT2-KD validation in microglia.
  • Fig. S3. Direct stimulation of TLR4 in microglia with KLA activates c-Src.
  • Table S1. Information about human donors.
  • Table S2. Antibodies used for immunohistochemistry.
  • Table S3. Antibodies used for immunocytochemistry.
  • Table S4. Antibodies used for Western blotting.
  • Table S5. Primers used for qRT-PCR.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 586 KB


Citation: C. C. Portugal, R. Socodato, T. Canedo, C. M. Silva, T. Martins, V. S. M. Coreixas, E. C. Loiola, B. Gess, D. Röhr, A. R. Santiago, P. Young, R. D. Minshall, R. Paes-de-Carvalho, A. F. Ambrósio, J. B. Relvas, Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype. Sci. Signal. 10, eaal2005 (2017).

© 2017 American Association for the Advancement of Science