Supplementary Materials

Supplementary Materials for:

p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM

Jacob Stewart-Ornstein and Galit Lahav*

*Corresponding author. Email: galit{at}hms.harvard.edu

This PDF file includes:

  • Text S1. MATLAB simulations.
  • Fig. S1. Cell-to-cell variation in p53 abundance is not because of genetic inhomogeneity.
  • Fig. S2. Proliferation and induction of p53 target genes after DNA damage across cell lines.
  • Fig. S3. Characterization of modulators of p53 dynamics.
  • Fig. S4. The fraction of unrepaired DNA breaks is cell line–specific and does not depend on the damage dose.
  • Table S1. Summary of chemical screening data.

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Citation: J. Stewart-Ornstein, G. Lahav, p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM. Sci. Signal. 10, eaah6671 (2017).

© 2017 American Association for the Advancement of Science